ABSTRACT
Introduction: The correlation between the level of IgG titers and disease severity during the acute phase of COVID19 is well described. However, rare data are available on possible association between IgG titre and post COVID syndrome (PCS). Method(s): It was a prospective study. HCW who presented to the post-COVID outpatient clinic, 3 months after recovery were included. HCW were asked about the acute phase of COVID-19 and PCS symptoms and had serum samples for SARS-CoV-2 IgG. Aim(s): analyse the incidence of PCS among health care workers (HCW) and correlation with SARS-COV2 IgG level. Result(s): 108 HCW were included (mean age: 42.12+/- 10.31 years, sex ratio was 0,4). Initially, 4.6% experienced severe disease. PCS was detected in 63% of cases. Main symptoms were memory impairment (36.8%), fatigue (35.3%), dry cough (32.4%), dyspnea (32.4%) and asthenia (29.4%). The incidence was 100%, 57,1% and 62,7% in patients with severe pneumonia, mild pneumonia and without pneumonia, respectively (p=0,079, p=0,45 and p=0,92) (The incidence was 7,4%, 23,5% and 69,1% in patients with severe pneumonia, mild pneumonia and without pneumonia, respectively (p=0,079, p=0,45 and p=0,92)). At Follow up, the IgG level was positive in 70.4% of cases with an average rate of 8.44. HCW with PCS, were more likely to have a positive IgG level (67% vs 32%;p=0,41). Moreover, IgG rate was higher in this population (9.06 vs 7,48;p=0,38). Patients with no IgG had 40% less possibility to have PCS symptoms. Conclusion(s): The present study confirmed a high incidence of PCS in HCW. These symptoms were associated to a higher level of IgG suggesting immunological mecanisms. Further studies are needed to confirm these data.